When you first slide a knee brace on, it is recommended to wear it for at least one week. Consider giving your leg a break by taking the knee brace off while sleeping. On the other hand, your doctor might instruct you to wear your knee brace while in bed. The movement in your sleep could undo what surgeon fixed, therefore you need to wear it to avoid further injury. Follow your doctor's recommendations and consult with them before increasing or decreasing the time during which you wear it.
Additional factors to consider when determining how often you should wear knee support for runners are as follows:
Wearing your knee brace for unnecessarily long stretches of time can cause skin abrasion
Limiting your range of motion while wearing your brace can result in muscle atrophy or joint stiffness
Taking off your brace before your knee joint is ready can impair healing and lengthen the time required to wear one
Neglecting to wear it when you are susceptible to an injury could possibly lead to further knee damage
So, be sure to check with your doctor and follow their advice.