Effect Runes determine what happens once the condition set by the Condition Rune is met. These Runes offer a variety of effects that can buff your character, deal additional damage, or provide healing. The possibilities are vast, and combining the right Effect Rune with Diablo 4 Gold a Condition Rune is key to unlocking powerful synergies.

Boosts your damage output for a short period.Heals your character when the condition is met.Unleashes AoE damage when triggered.Reduces the cooldown of specific abilities.

The beauty of the Rune system lies in the variety of effects you can choose, making it a versatile tool for any playstyle, whether you're focused on dealing massive damage, surviving long battles, or supporting your allies.

To fully utilize the Rune system, you'll need to combine Condition Runes and Effect Runes to create Rune Words. These are special pairings that can dramatically enhance your character's abilities. For example, pairing a Condition Rune that triggers on a critical hit with an Effect Rune that deals AoE damage creates a powerful synergy where every critical hit causes an explosion of damage around your target.

Collect Condition and Effect Runes: Runes can drop from enemies, chests, or be acquired through quests. Condition Runes and Effect Runes are collected separately, and you'll need both types to create a buy D4 Gold Word.